For the past several years, we have taken our network science approach and have begun to apply it to the management of commensal macaques in South and Southeast Asia. We are interested in these commensal macaques as a natural coupled system with humans and thus the mechanisms that drive human-macaque interaction patterns across different macaque species. The goal of this work is to develop best management practices for resolving conflict between humans and these commensal populations of macaques as well as to develop a free-ranging translational model for human health research that benefits both humans and nonhuman primates. We are finding that humans play a large role in the conflict generated at this interface due to a lack of understanding of macaques and their behavior. We also are beginning to look at the potential for disease transmission dynamics within and across human-monkey networks.